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. Author manuscript; available in PMC: 2021 Feb 25.
Published in final edited form as: Curr Biol. 2020 Dec 22;31(4):794–808.e6. doi: 10.1016/j.cub.2020.11.058

Figure 6. The Cdk1 and PP2A Switches Both Contribute to Bistability.

Figure 6.

The dose-response relationship of the phosphorylation state of several Cdk1 substrates shown in (A) and (C) as well as the Cdk1 activity shown in (B) and (D) were measured in the presence of 0.5 μM OA and in the absence (A and B) or presence (C and D) of the Wee1/Myt1 inhibitor (10 μM PD0166285). Hysteresis was still detectable if only PP2A activity was partially inhibited, but was almost abolished if Wee1 was inhibited in addition. The measurements were performed in parallel using the same extract. Cdk1 activity is shown as the mean of a technical duplicate with connecting lines.