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. 2020 Oct 20;78(4):1355–1367. doi: 10.1007/s00018-020-03666-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Impact of SRCIN1/p140Cap gene alteration in ERBB2/HER2-amplified breast cancer and neuroblastoma. Amplification of the SRCIN1 gene in ERBB2/HER-2-positive breast cancer patients impairs tumor growth and metastasis mainly through the down-regulation of Tiam1/Rac1 axis. SRCIN1 aberrant alterations such as translocations, deletions or loss of heterozygosity promote tumor growth, metastasis and drug resistance in NB patients, consistent with the loss of p140Cap expression, and inhibition of both Src and STAT3/Jak2 pathways