Table 2.
Univariate and multivariate analyses for RFS and OS in patients with HCC
| Variables | RFS | OS | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Univariate analysis | ||||
| Age (years) | 1.01 (0.98–1.04) | 0.516 | 0.99 (0.97–1.02) | 0.537 |
| Albumin (g/L) | 0.87 (0.78–0.97) | 0.013 | 0.88 (0.81–0.95) | 0.001 |
| WBC (109/L), mean (SD) | 0.84 (0.68–1.04) | 0.115 | 1.09 (0.93–1.30) | 0.295 |
| Neutrophil (109/L), mean (SD) | 0.82 (0.63–1.07) | 0.138 | 1.14 (0.92–1.40) | 0.23 |
| Lymphocyte (109/L), mean (SD) | 0.63 (0.32–1.22) | 0.168 | 0.75 (0.44–1.26) | 0.274 |
| Monocyte (109/L), mean (SD) | 0.59 (0.10–3.45) | 0.559 | 3.91 (0.90–17.08) | 0.069 |
| PLT (109/L) | 1.00 (1.00–1.01) | 0.54 | 1.00 (1.00–1.01) | 0.189 |
| Total bilirubin (μmol/L) | 0.99 (0.97–1.01) | 0.394 | 1.00 (0.97–1.02) | 0.734 |
| Direct bilirubin (μmol/L) | 0.98 (0.94–1.03) | 0.411 | 0.99 (0.95–1.04) | 0.672 |
| ALT (U/L) | 1.01 (0.99–1.03) | 0.24 | 1.00 (0.99–1.01) | 0.923 |
| AST (U/L) | 1.00 (0.99–1.01) | 0.794 | 1.00 (0.99–1.00) | 0.291 |
| APTT (s) | 1.01 (0.92–1.11) | 0.796 | 0.97 (0.91–1.03) | 0.313 |
| PT (s) | 1.02 (0.69–1.51) | 0.925 | 0.97 (0.73–1.29) | 0.843 |
| Tumor diameter (cm) | 1.29 (1.09–1.53) | 0.004 | 1.19 (1.08–1.32) | 0.001 |
| Creatinine (μmol/L) | 0.99 (0.97–1.01) | 0.352 | 1.00 (0.98–1.01) | 0.534 |
| HBV (presence vs. absence) | 1.99 (0.57–6.96) | 0.284 | 1.00 (0.48–2.12) | 0.991 |
| Tumor capsular (absence vs. presence) | 1.04 (0.45–2.41) | 0.929 | 1.07 (0.58–1.95) | 0.835 |
| AFP (ng/mL) (> 20 vs. ≤ ) | 1.06 (0.48–2.36) | 0.885 | 1.50 (0.84–2.69) | 0.169 |
| Edmondson grade (III–IV vs. I–II) | 1.86 (0.67–5.13) | 0.232 | 1.51 (0.78–2.90) | 0.218 |
| Tumor number (multiple vs. single) | 3.44 (1.00–11.84) | 0.051 | 1.61 (0.83–3.13) | 0.157 |
| PNI (high group vs. low group) | 0.17 (0.07–0.39) | 0.01 | 0.31 (0.17–0.57) | 0.02 |
| SII (high group vs. low group) | 1.23 (0.54–2.77) | 0.625 | 2.08 (1.15–3.76) | 0.016 |
| Sex (male vs. female) | 3.34 (0.76–14.72) | 0.111 | 1.95 (0.89–4.25) | 0.094 |
| Cirrhosis (presence vs. absence) | 1.46 (0.64–3.35) | 0.369 | 1.19 (0.63–2.26) | 0.587 |
| TNM stage (III vs. I/II) | 2.40 (0.69–8.36) | 0.169 | 1.79 (0.86–3.73) | 0.122 |
| Multivariate analysis | ||||
| Albumin (g/L) | 1.07 (0.92–1.25) | 0.377 | 0.98 (0.88–1.09) | 0.705 |
| PNI (high group vs. low group) | 0.11 (0.03–0.39) | 0.001 | 0.43 (0.19–1.00) | 0.049 |
| SII (high group vs. low group) | 1.14 (0.46–2.87) | 0.776 | 1.98 (1.04–3.77) | 0.039 |
| Tumor number (multiple vs. single) | 2.41 (0.64–9.20) | 0.194 | ||
| Tumor diameter (cm) | 1.27 (1.04–1.54) | 0.018 | 1.20 (1.08–1.33) | 0.001 |
WBC white blood cell, PLT platelet, ALT alanine transaminase, AST aspartate transaminase, PT prothrombin time, PNI prognostic nutritional index, SII systemic immune-inflammation index, AFP alpha-fetoprotein, TNM tumor-node-metastasis