Table 2.

Correlation between imaging biomarkers and complement factors

	N	Drusen volume		Reticular pseudodrusen		Hyperreflective foci
		P value	Correlation coefficient	P value	Correlation coefficient	P value	Correlation coefficient
Total protein	94	0.226	0.126	0.364	0.095	0.761	0.032
C3	98	0.077	0.180	0.257	0.116	0.377	0.090
C3a	93	0.057	0.198	0.210	0.131	0.380	0.092
C3b/i C3b	56	0.034	0.285	0.152	0.194	0.395	0.116
Ba	100	0.009	0.262	0.090	0.170	0.087	0.172
C4	99	0.931	0.009	0.238	0.120	0.551	0.061
C5	42	0.005	0.430	0.133	0.236	0.011	0.388
CFB	100	0.115	0.159	0.050	0.196	0.103	0.164
CFD	99	0.935	− 0.008	0.362	0.093	0.758	0.031
CFH	90	0.273	0.117	0.106	0.171	0.142	0.156
CFI	96	0.451	0.078	0.135	0.154	0.567	0.059

Complement factors 3a (C3a), Ba, C3b/iC3b; complement factors B, D, H, and I (CFB, CFD, CFH, CFI); complement proteins 3 (C3), 4 (C4), 5 (C5); CI, confidence interval; OR, odds ratio