Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 30;78(4):1163–1189. doi: 10.1007/s00018-020-03649-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — Alterations of circuitry and main findings of glucocorticoid/dopamine/BDNF signaling in socially avoidant animals. The mesocorticolimbic system consisting of VTA, PFC, and NAc is in the center of regulating stress-induced social avoidance in preclinical models. Projections with either activity-increase (plus) or -decrease (minus) determine the level of transmitter-release and expression of other modulators and their receptors in the target region (position of arrowhead). BDNF brain-derived neurotrophic factor, CRH corticotropin-releasing hormone, D1R and D2R dopamine receptor 1 and 2, DA dopamine, GR glucocorticoid receptor)