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. 2020 Sep 9;383(2):835–852. doi: 10.1007/s00441-020-03270-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a–e The effect of different anti-camel MOs varies depending on the target. MO1 targets all isoforms causing the most severe effect, including the hydrocephalus, curled trunk, and edema. MS1 and MS2 target specific mRNA isoforms (1 + 3 and 1 + 2, correspondingly). MS1 causes the hydrocephalus and mildly curled trunk. MS2 causes hydrocephalus. The effect of MS1 and MS2 is additive in enhancing the trunk curvature. 50 embryos were observed in each experiment repeated three times. The phenotypes representing 95% of experimental animals were selected. Scale bar = 50 μm