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. 2021 Feb 24;11:4504. doi: 10.1038/s41598-021-83888-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Overall permeabilization strategies. Proteolysis covers all treatment with proteinase K, regardless of the duration of exposure (2.5–20 min). TRS pH 6.1 = Heat-induced microRNA Retrieval (HmiRR) with Target Retrieval Solution (TRS) pH 6.1 regardless of enzymatic treatment with pepsin. TRS pH 9 = HmiRR with TRS pH 9 regardless of enzymatic treatment with pepsin. All horizontal bars indicate statistical comparison of groups. The numbers above the horizontal bars are p values determined using a Wilcoxon signed-rank test. The figure was constructed with the statistical software R.