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. 2021 Feb 24;7:37. doi: 10.1038/s41420-021-00418-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The synovial fluid of NON-OA and OA patients was obtained. Then the extracellular vesicles obtained by ultrafiltration assay were collected and analyzed. B The indicated protein levels (CD63 and CD81) in exosome-like vesicles were detected by western blotting. C The morphology of exosome-like vesicles was observed under TEM and NanoSight detection was measured. D Heatmap label for aberrantly expressed miRNAs in synovial fluid exosomes of patients with OA. E, F The KEGG pathway annotation and GO analysis were performed.