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. 2021 Feb 24;12:1269. doi: 10.1038/s41467-021-21247-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a ALT frequency detected using C-Circle presence as a marker in the screening cohort (n = 720, left) and INFORM cohort (n = 40, right). Top pies illustrate the composition of the cohorts concerning INSS tumor stage. b Schematic overview of the analyzed patient cohorts used for C-Circle screening and high-throughput analysis using whole genome sequencing (WGS), RNA-sequencing, whole proteome analysis, and ChIP-sequencing. Sample numbers are given in brackets. Number of C-Circle positive (CC+) and C-Circle negative (CC-) patients in the sub-cohorts are indicated.