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. 2021 Feb 24;12:1269. doi: 10.1038/s41467-021-21247-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Relative telomere content (tumor/control) of neuroblastoma tumors in the discovery cohort grouped according to the genetic evidence of an active telomere maintenance mechanism (see methods for details): ALT activation (ALT, red), telomerase activation by amplified MYCN (MNA, yellow), structural variation affecting TERT or TERT promoter mutation (TERT, blue), and patients having no genetic evidence of an activated telomere maintenance mechanism (OTHER, gray). b TERT mRNA expression in different subgroups. c Expression of the telomeric repeat-containing RNA TERRA in the different subgroups. a–c Boxplots indicate the median value (middle line), the 25th and 75th percentiles (box). The upper/lower whisker spans from the hinge to the largest/smallest value (values expanding a distance of 1.5 x inter quartile range are not considered). Dots represent individual tumors. P values were calculated with two-sided Wilcoxon rank sum tests. d Event-free and overall survival probability compared between ALT-positive (n = 60) and MYCN-amplified (MNA, n = 34) neuroblastomas. e Event-free and overall survival probability of patients with ALT-positive tumors classified as low or intermediate risk (LR/IR, n = 20) compared to patients with ALT-positive tumors classified as high-risk (HR, n = 39) using the NB2004 risk stratification. d–e P values were calculated using log rank tests. a–e n describes the number of analyzed tumors.