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. 2021 Feb 24;11:4495. doi: 10.1038/s41598-021-84044-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Scatter plot of average reported concordance scores and standard deviation (SD) of reported concordance scores for candidate drugs. A total of 83 FDA approved drugs were identified in the SARS-CoV-2 A549_ACE2 dataset (GSE147507 CL). 57 drugs were identified with a minimum mean concordance score 0.47and SD ≤ 0.08 (squares). Drugs above this threshold are considered “candidate” drugs. Top candidate drugs, those approved for use in humans and with demonstrated antiviral activity in vitro (filled triangles), those with SARS-CoV-2 antiviral efficacy specifically (inverted triangles) and those already in trial for COVID-19 (diamond) are also identified.