Table 3.
Multivariate Cox regression analysis on the risk factors associated with mortality in patients.
| Variables | Model 1 | Model 2 | Model 3 | Model 4 | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) |
P value | HR (95%CI) | P value | |
| Age | 1.03 (1.01, 1.06) | 0.016 | 0.083 | 0.014 | 0.058 | |||
| COPD | 0.053 | 0.093 | 0.030 | 0.063 | ||||
| SpO2, % | 0.391 | 0.330 | 0.276 | 0.391 | ||||
| Leukocytes, × 103/μL | 0.696 | 0.903 | 0.770 | 0.696 | ||||
| Platelets, × 103/μL | 0.215 | 0.103 | 0.070 | 0.215 | ||||
| Lymphocytes, × 103/μL | 0.304 | 0.464 | 0.439 | 0.304 | ||||
| AST, U/L | 0.186 | 0.937 | 0.386 | 0.186 | ||||
| LDH,U/L | 0.401 | 0.758 | 0.322 | 0.401 | ||||
| hs-CRP, mg/L | 1.44 (1.12, 1.85) | 0.004 | 1.39 (1.08, 1.79) | 0.011 | 1.43 (1.12, 1.82) | 0.004 | 1.44 (1.12, 1.85) | 0.004 |
| D-dimer, μg/mL | 1.47 (1.28, 1.71) | < 0.001 | 1.36 (1.18, 1.58) | < 0.001 | 1.46 (1.26, 1.68) | < 0.001 | 1.48 (1.28, 1.71) | < 0.001 |
| Serum ferritin, ng/mL | 0.055 | 0.330 | 0.321 | 0.055 | ||||
| ESR, mm/h | 0.288 | 0.115 | 0.420 | 0.288 | ||||
| Interleukin 6, pg/mL | 0.192 | 0.150 | 0.132 | 0.192 | ||||
| hs-TnI, pg/mL | 0.218 | – | – | – | ||||
| Myohemoglobin, ng/mL | – | 1.41 (1.11, 1.80) | 0.005 | – | – | |||
| CK-MB, U/L | – | – | 1.50 (1.10, 2.06) | 0.012 | – | |||
| Cardiac injury | – | – | – | 2.63 (1.38, 5.65) | 0.016 | |||
Cardiac biomarkers were included in Model 1, 2, 3 separately as continuous variables. Cardiac injury was included in Model 4 as binary variable.