Table 2.

Frequency of consensus ROHs with a potential risk or protective effect in Alzheimer’s disease.

	N ROH	Risk associations	Protective associations	P value	Probability of success
Whole dataset	21190	11974	9216	< 2.2 × 10−16	0.56
Category A	1017	593	424	< 2.2 × 10−16	0.58
Category B	926	537	389	1.30 × 10−6	0.57
Category C	858	499	359	1.98 × 10−6	0.58
Category D	42	33	9	2.7 × 10−4	0.79
Whole dataset/map of inbreed AD cases	6636	3969	2667	< 2.2 × 10−16	0.60

Strategy A, ROHs > 100 kb; >3 SNPs.

Strategy B, ROHs > 100 kb; >25 SNPs.

Strategy C, ROHs > 100 kb; >50 SNPs.

Strategy D, ROHs > 100 kb; >3 SNPs, P < 0.05.