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. 2021 Feb 24;12(2):211. doi: 10.1038/s41419-021-03493-2

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A, B ALT and AST activities in the perfusate. Data are mean ± SD, **P < 0.01 by one-way ANOVA followed by Tukey’s test. n = 6 per group. C, D MDA and SOD activities in rat liver tissues. Data are mean ± SD, **P < 0.01 by one-way ANOVA followed by Tukey’s test. n = 6 per group. E (a) Histological damage in liver of rats. H&E staining was performed on paraffin-embedded section of rat liver tissues. Scale bar = 200 μm (left panels) and 50 μm (right panels). E (b) Changes in the microstructure of hepatocytes. The changes of hepatocellular microstructure were observed using TEM. N, nucleus; M, mitochondria; r, rough endoplasmic reticulum; S, smooth endoplasmic reticulum. The black arrows indicate the lacuna between the inner and outer membranes of mitochondria. Scale bar = 2 μm (left panels) and 500 nm (right panels). E (c, d) Activation of LSECs. IHC staining (c) and IF staining (d) of CD31 and CD206 were performed on paraffin-embedded section of rat liver tissues. Scale bar = 100 μm. F Histological scores were analyzed based on Suzuki’s criteria. Data are mean ± SD, **P < 0.01 by one-way ANOVA followed by Tukey’s test. n = 6 per group. G, H IHC and IF stained fluorescence of CD31 and CD206 were quantified using Image-pro plus 6.0. Data are mean ± SD, *P < 0.05 and **P < 0.01 by two-way ANOVA followed by Tukey’s test. n = 6 per group.