Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 24;12:1274. doi: 10.1038/s41467-021-21515-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Isolation and UMAP visualization of human VISp glutamatergic neurons from all cells (top right), colored by punch position. An interactive, three-dimensional UMAP embedding is available as Supplementary Data 4. b ATAC-seq profiles for glutamatergic neurons along trajectory positions for layer (L)-specific marker genes CALB1 (layers 2 and 3), LMO4 (layer 5), and CTGF (layer 6b); colored by punch position as in a. c Cells from section 1, Trajectory 4 (T1.4, top) are shown in color on the UMAP of all cells, with other cells shown in gray (bottom); colored by position as in a. d UMAP of glutamatergic neurons from Trajectory 1.4 after topic modeling on the isolated cells; colored by position along the trajectory as in a. e DNA-binding motif enrichment for layer-specific factors for Trajectory 1.4 shown in d, with cells split by their positions along the trajectory. Source data are provided as a Source data file.