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. 2021 Feb 24;12(2):210. doi: 10.1038/s41419-021-03490-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A2780, CAOV3, ES2 and SKOV3 ovarian cancer cells were treated with 0 μg, 50 μg, and 100 μg of #7 ADEs. a Representative images of wound-healing assays of A2780 and SKOV3 and the area of wound closure was measured. Scale bar, 100 μm. b Representative images from migration and invasion assays of A2780 and SKOV3 cells. Scale bar, 100 μm. c Invaded and migrated cells were counted and are shown as histograms. d, e Changes in the morphology of A2780 and CAOV3 cells were evaluated by microscopic observation and F-actin staining. Scale bar, 100 μm (d), Scale bar, 20 μm (e). f Western blot analysis of E-cadherin, N-cadherin and Vimentin expressions in A2780, CAOV3, ES2 and SKOV3 cells. g Immunofluorescence analysis of E-cadherin, N-cadherin, and Vimentin in A2780 and CAOV3 cells. Experiments were performed in at least triplicate, and the results are shown as the mean ± s.d. values. Student’s t test was used to analyze the data (NS, not significant; *p < 0.05; **p < 0.01; ***p < 0.001). Scale bar, 20 μm.