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. 2021 Feb 24;12(2):210. doi: 10.1038/s41419-021-03490-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Mice bearing SKOV3-luc orthotopic xenotransplants were injected intraperitoneally with #7 ADEs or PBS. a Bioluminescence images of abdominal metastasis in mice bearing SKOV3-luc orthotopic xenotransplants. b Growth curve of SKOV3-luc tumors based on the quantitative radiance values from IVIS imaging. (c) Bioluminescence images of metastases on abdominal organs. The organs arranged clockwise from the top are the liver, spleen, kidneys, pancreas, and omentum. d Quantitative radiance values from IVIS imaging in metastases on abdominal organs. e, f The size and weight of the ovarian primary tumors from each group of nude mice. g Immunohistochemical analysis of the expression of E-cadherin, N-cadherin, and Vimentin in tumor tissues. Scale bar, 20 μm. h Diagram of the calculated percentage of Ki67 staining and mean density of E-cadherin, N-cadherin, and Vimentin in the two groups (*p < 0.05; **p < 0.01; ***p < 0.001).