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. 2021 Feb 11;12:599526. doi: 10.3389/fimmu.2021.599526

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Copyright © 2021 Binder, Sellberg, Cvetkovski, Berg, Berglund and Berglund

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD69 and CD2 expression on NK cells after 7 days of mixed lymphocyte reaction. Significance testing was conducted via one-way ANOVA with untreated controls (no antibody) serving as the comparison data set (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). Siplizumab, deglycosylated (DG) siplizumab, Fc-silent (FcS) anti-CD2 IgG1, FcS anti-CD2 IgG2 and FcS anti-cD2 IgG4 were used at 0.0001–10 µg/ml. Data displayed as mean percentage of CD69⁺ NK cells ± SD (A) or average median CD2 fluorescence intensity +SD [CD2 MFI, (B); n=9). (C) Representative dot plots of CD2 and CD69 expression on NK cells in untreated controls (no antibody) or 10 µg/ml anti-CD2.