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. 2021 Feb 11;12:599526. doi: 10.3389/fimmu.2021.599526

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Copyright © 2021 Binder, Sellberg, Cvetkovski, Berg, Berglund and Berglund

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Natural NK cell cytotoxicity. Purified NK cells were pre-incubated without antibody, with 0.001–10 µg/ml Siplizumab or 0.001–10 µg/ml Fc-silent (FcS) anti-CD2 IgG antibodies for 30 min (A) or 2 days (B) followed by addition of HLA class I^- target cells (SPI-801). Significance testing was conducted via one-way ANOVA with untreated controls (no antibody) serving as the comparison data set (N=6; *p < 0.05, **p < 0.01, ***p < 0.001). (C) Representative histograms of NK cell degranulation in response to HLA class I^- target cells without addition of antibody (NK+SPI-801), without addition of antibody and HLA class I^- target cells (NK) or in the presence of Siplizumab/FcS anti-CD2 IgG1.