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. 2021 Feb 11;11:563085. doi: 10.3389/fcimb.2021.563085

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Copyright © 2021 Alipoor, Mortaz, Jamaati, Tabarsi, Bayram, Varahram and Adcock

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic of genome encoding spike protein in SARS-CoV2. SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding domain; RBM, receptor-binding motif; FP, fusion peptide; HR1 and HR2, heptad repeat regions 1 and 2; TM, transmembrane; CP, cytoplasmic domain. (B) Schematic drawing of the structure of coronavirus spike. S1, receptor-binding subunit (homotrimers); S2, membrane fusion subunit; TM, transmembrane anchor; IC, intracellular tail. (C) SARS-CoV-2 spike ectodomain structure (open state) (details provided at https://www.rcsb.org/structure/6VYB).