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. 2021 Feb 11;15:638772. doi: 10.3389/fnins.2021.638772

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Copyright © 2021 Fu and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neuroprotective effects of ISL on N2a cells cultured with conditioned medium from AβO stimulated BV2 cells. (A) A diagram of the toxic effect of conditioned media from AβO stimulated BV2 cells on N2a cells with or without the ISL pre-treatment. (B,C) N2a cells were treated with conditioned medium for 24 h and cell viability was assessed using MTT and LDH cytotoxicity assays. *p < 0.05; **p < 0.01, ***p < 0.001. n = 6 per group.