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. 2021 Feb 24;12:1258. doi: 10.1038/s41467-020-20851-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The x-axes show POAG effect estimates in log(OR) scale for the independent genome-wide significant loci obtained from the cross-ancestry meta-analysis. The y-axes show the effect estimates for the same SNPs obtained from the meta-analysis of IOP in UKBB + IGGC (mmHg scale; a) and the meta-analysis of VCDR in UKBB + IGGC (b). Blue line shows the regression line for IOP (a) and VCDR loci (b). Orange dots represent SNPs having P < 0.05 for IOP, purple dots P < 0.05 for VCDR, green dots P < 0.05 for both IOP and VCDR, and blue dots P > 0.05 for both IOP and VCDR. Horizontal gray bars on each dot represent the 95% confidence intervals (CIs; mean values + / − 1.96*SEM) for the POAG effect estimates (34,179 cases vs. 349,321 controls), and vertical gray bars shows the 95% CIs for IOP (N = 133,492; a) and VCDR (N = 90,939; b). The shaded area shows the 95% CIs on the repression line. Although none of the blue dots show an expected trend of association with IOP in a (their 95% CIs do not overlap with the regression line), the majority of them show a trend of association for VCDR in b. UKBB UK Biobank, IGGC International Glaucoma Genetics Consortium, IOP intraocular pressure, VCDR, vertical cup-to-disc ratio, POAG primary open-angle glaucoma, OR odds ratio.