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. 2021 Jan 7;15(1):93–105. doi: 10.1007/s12079-020-00598-9

Table 3.

LoF mutations in the CCN gene family

Gene ORF (kb) Expected LoF mutants Observed LoF mutants Observed/expected (90% range) pLI Null mouse phenotype
CCN1 (Cyr61) 1.1 17.2 3 0.17 (0.08–0.45) 0.71 Embryonic or perinatal lethal
CCN2 (CTGF) 1.0 12.4 7 0.56 (0.32–1.06) 0.0 Perinatal lethal
CCN3 (NOV) 1.1 14.7 6 0.41 (0.22–0.81) 0.01 Viable
CCN4 (WISP1) 1.1 17.3 12 0.69 (0.44–1.13) 0.0 Viable
CCN5 (WISP2) 0.8 9.8 8 0.82 (0.48–1.46) 0.0 Viable
CCN6 (WISP3) 1.2 17.1 8 0.47 (0.27–0.84) 0.0 Viable