Table 3.
Gene | ORF (kb) | Expected LoF mutants | Observed LoF mutants | Observed/expected (90% range) | pLI | Null mouse phenotype |
---|---|---|---|---|---|---|
CCN1 (Cyr61) | 1.1 | 17.2 | 3 | 0.17 (0.08–0.45) | 0.71 | Embryonic or perinatal lethal |
CCN2 (CTGF) | 1.0 | 12.4 | 7 | 0.56 (0.32–1.06) | 0.0 | Perinatal lethal |
CCN3 (NOV) | 1.1 | 14.7 | 6 | 0.41 (0.22–0.81) | 0.01 | Viable |
CCN4 (WISP1) | 1.1 | 17.3 | 12 | 0.69 (0.44–1.13) | 0.0 | Viable |
CCN5 (WISP2) | 0.8 | 9.8 | 8 | 0.82 (0.48–1.46) | 0.0 | Viable |
CCN6 (WISP3) | 1.2 | 17.1 | 8 | 0.47 (0.27–0.84) | 0.0 | Viable |