Table 4.

LoF mutations in tenascins

Gene	ORF (kb)	Expected LoF mutants	Observed LoF mutants	Observed/expected (90% range)	pLI	Null mouse phenotype
TNC	6.6	91.4	30	0.33 (0.24–0.45)	0.00	Viable
TNXB	2.0b	21.8	7	0.32 (0.18–0.6)	0.02	Viable
TNN	3.9	59.6	49	0.82 (0.65–1.04)	0.00	Pending*
TNR	4.1	72.4	16	0.22 (0.15–0.34)	0.52	Viable

*Mouse registered but phenotype not currently available at www.mousephenotype.org

^bIsoform 2