Table 2.
Gene Set Enrichment and Pathway Analyses of the Hub Genes
| Biological Process | Count | Adj P value | Cellular Component | Count | Adj P value |
|---|---|---|---|---|---|
| cell cycle G2/M phase transition | 6 | 7.09E-07 | spindle | 5 | 8.19E-05 |
| G2/M transition of mitotic cell cycle | 6 | 1.35E-06 | spindle midzone | 3 | 3.05E-04 |
| regulation of cell cycle process | 5 | 8.13E-06 | nuclear chromosome part | 5 | 8.03E-04 |
| mitotic cell cycle phase transition | 6 | 9.99E-06 | spindle microtubule | 3 | 9.16E-04 |
| DNA damage response, signal transduction by p53 class mediator | 4 | 2.94E-04 | mitotic spindle | 3 | 2.33E-03 |
| anaphase-promoting complex-dependent catabolic process | 4 | 3.04E-04 | condensed nuclear chromosome kinetochore | 2 | 2.57E-03 |
| regulation of ubiquitin protein ligase activity | 3 | 1.75E-03 | spindle pole | 3 | 4.12E-03 |
| regulation of G2/M transition of mitotic cell cycle | 4 | 2.42E-03 | centrosome | 4 | 1.73E-02 |
| mitotic nuclear envelope disassembly | 3 | 2.52E-03 | microtubule | 3 | 2.11E-02 |
| nuclear envelope disassembly | 3 | 2.59E-03 | microtubule organizing center | 4 | 2.21E-02 |
| Molecular Function | Count | Adj P value | KEGG pathway | Count | Adj P value |
| protein kinase binding | 7 | 3.40E-05 | progesterone-mediated oocyte maturation | 5 | 2.39E-06 |
| kinase binding | 6 | 1.97E-04 | systemic lupus erythematosus | 5 | 5.29E-06 |
| cyclin-dependent protein kinase activity | 3 | 7.73E-04 | alcoholism | 5 | 1.60E-05 |
| protein serine/threonine kinase activity | 5 | 1.52E-03 | oocyte meiosis | 4 | 1.16E-04 |
| histone kinase activity | 2 | 4.34E-03 | cell cycle | 4 | 1.40E-04 |
| protein kinase activity | 5 | 5.07E-03 | cellular senescence | 4 | 2.58E-04 |
| cyclin-dependent protein serine/threonine kinase activity | 2 | 4.50E-02 | viral carcinogenesis | 4 | 5.45E-04 |