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. 2021 Feb 11;9:605272. doi: 10.3389/fcell.2021.605272

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Copyright © 2021 Huo, Lomora, Kym, Palivan, Holland-Cunz and Gros.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of AQP1 and its effect on hypoxia-related factors. AQP1 mRNA expression of migrating SH-SY5Y and Kelly neuroblastoma cells is decreased through AQP1 inhibition by both the AQP1 inhibitor and in case of SH-SY5Y cells through the AQP1 knock-down construct. HIF-1α expression is not compromised in the knock-down and only partially under AQP1 inhibition. HIF-2α expression is down-regulated in the SH-SY5Y AQP1 knock-down and through AQP1 inhibition, while changes of PGK1 expression in either are not relevant. The experiment was performed twice, RNA triplicates were used for qPCR analysis each time and student’s t-test for analysis of data.