TABLE 1.

Activation of classical NFκB and cell death signaling by category I and category II TNFRs in response to soluble TNF ligands (sTNFLs).

TNFR	Category	TNFL	sTNFL variant/activity (EC50 trimer: EC50 hexa-, nonamer, etc.)		sTNFL variant/activity (EC50 no anchoring: EC50 PM anchoring)
				References		References
BaffR	I	Baff	Flag-Baff/>100	Bossen et al., 2008
			Baff 64-mer/>100
DR3	I	TL1A	Flag-TNC-TL1A/1	Bittner et al., 2016
GITR	I	GITRL	Flag-TNC-GITRL/5	Wyzgol et al., 2009; Richards et al., 2019	Sc40-GITRL/5	Wyzgol et al., 2009
			HERA-GITRL/10
LTbR	I	LTab2	Flag-scLTab2/1	Lang et al., 2016
		LIGHT	Flag-TNC-LIGHT/1	Lang et al., 2016
TNFR1	I	TNF	Flag-TNF/1	Schneider et al., 1998
		LTa	Flag-TNC-LTa/1	Lang et al., 2016
41BB	II	41BBL	Flag-TNC-41BBL/>100	Wyzgol et al., 2009	Sc40-41BBL	Wyzgol et al., 2009
BCMA	II	APRIL	Flag-APRIL/>20	Bossen et al., 2008
CD27	II	CD27L	Flag-TNC-CD27L/>100	Wyzgol et al., 2009
CD40	II	CD40L	Flag-CD40L/20	Holler et al., 2003; Wyzgol et al., 2009	Sc40-CD40L/20	Wyzgol et al., 2009; Brunekreeft et al., 2014
			Flag-CD40L/>>100		scFv:EpCAM-CD40L/20
CD95	II	CD95L	Flag-CD95L/>1,000	Schneider et al., 1998; Holler et al., 2003	Sc40-CD95L/>>100	Samel et al., 2003
			Fc-CD95L/>1,000
			ACRP-CD95L > 1,000
EDAR	II	EDA-A1	Flag-EDA-A1/>>100	Swee et al., 2009
Fn14	II	TWEAK	Flag-TWEAK/>1,000	Roos et al., 2010	Sc40-TWEAK/>>100	Roos et al., 2010
			Fc-TWEAK/>>100
OX40	II	OX40L	Flag-OX40L/>100	Muller et al., 2008	Sc40-OX40L/>100	Muller et al., 2008
			Fc-OX40L/>20
TACI	II	APRIL	Flag-APRIL/>100	Bossen et al., 2008
		Baff	Flag-Baff/>100	Bossen et al., 2008
			Baff 64-mer/>100
TNFR2	II	TNF	Flag-TNF/100	Schneider et al., 1998; Prada et al., 2020
			TNC-scTNF(143N/145R)/>1,000
TRAILR1	II	TRAIL	Flag-TNC-TRAILmutR1/100	Trebing et al., 2014a	scFv:CD70-TNC-TRAILmutR1/100	Trebing et al., 2014a
TRAILR2	II	TRAIL	Flag-TRAIL/>1,000	Schneider et al., 1998; Wajant, 2019	AD-TRAILs > 100	Wajant, 2019
			Oligomeric TRAILs/>100

Please note that this is a non-exhaustive table listing representative reports.