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. 2021 Feb 11;9:630353. doi: 10.3389/fcell.2021.630353

FIGURE 3.

FIGURE 3

Restoration of FVIII function in HA mice using F8-modified iPSC-derived iMSCs. (A) Relative FVIII activity was detected 1–4 weeks after transplantation. HA mice, untreated HA mice; HA-iMSCs, HA mice transplanted with HA-iMSCs; 17-9-iMSCs, HA mice transplanted with 17-9-iMSCs; T-7-iMSCs, HA mice transplanted with T-7-iMSCs; hiMSCs, HA mice transplanted with hiMSCs. Bars represent the mean ± SEM, n = 5–6; ns, not significant, ***p < 0.001, **p < 0.01, and *p < 0.05 compared with HA mice (one-way ANOVA). (B) The data in (A) are shown as a line graph to describe the changes in FVIII activity during the 4-week observation period. (C) Liver and (D) lung tissue sections of iMSC-treated HA mice were analyzed using immunofluorescence; red fluorescence represents CM-Dil-positive cells, and DAPI was used for nuclear staining.