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. 2021 Feb 11;10:619317. doi: 10.3389/fonc.2020.619317

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Copyright © 2021 Liu, Tao, Wang, Yang, Yang, Dai, Ding, Wu, Chen and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Doxycycline inhibits pancreatic cancer growth and enhances the therapeutic effect of 5-FU. (A–E) The sensitization effect of doxycycline for chemotherapeutic drugs in Panc-1 cells after 72 h treatment. (F, G) The tumor volume change of Panc-1 subcutaneous xenografts in doxycycline, 5-FU, and the combination treatment group. (H) Immunohistochemical staining for E-cad, VIM, and CD133 in tumor tissues. Data are shown as the mean ± SD (*P < 0.05, **P < 0.01). (I) Molecular mechanism of doxycycline inhibits cancer stem cell-like properties of pancreatic cancer.