Figure 7.

Loss of ASC or NLRP3 increases the number of corpora lutea in reproductively aged mice. (A) Representative images of whole ovarian sections of 2, 6, 12, and 18-month-old WT, Asc^−/−, and Nlrp3^−/− mice. White asterisks indicate corpora lutea. Scale bars are 400 μm. Corpora lutea numbers (B) in ovaries from 2, 6, 12, and 18-month-old WT, Asc^−/−, and Nlrp3^−/− mice. Ovarian volume (C) for 2, 6, 12, and 18-month-old WT, Asc^−/−, and Nlrp3^−/− mice. n = 4–6 per cohort. All data are presented as mean ± SEM. For each age group, comparisons were made with WT using Student's t-test (*p < 0.05, **p < 0.01, ***p < 0.001).