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. 2021 Feb 11;10:583984. doi: 10.3389/fonc.2020.583984

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Copyright © 2021 Song, Wang, Shi, Lu, Yuan and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SH3KBP1 is highly expressed in GBM. (A) The expression of SH3KBP1 in glioma was increased with the tumor grade in TCGA data set. (B) High expression of SH3KBP1 predicts worse survival of glioma patients in TCGA data set. (C) SH3KBP1 expression was highly expressed in Isocitrate dehydrogenase1 (IDH1) wild-type gliomas than mutant gliomas in TCGA data set. (D) SH3KBP1 expression was correlated with glioma grades in CGGA datasets. (E) Elevated expression of SH3KBP1 predicts poor survival of glioma patients in CGGA data set. (F) SH3KBP1 was highly expressed in IDH1 wild-type gliomas than mutant gliomas in CGGA data set. (G) The expression of SH3KBP1 in glioma was increased with the tumor grades in Rembrandt data set. (H) High expression of SH3KBP1 predicts unfavorable survival of glioma patients in Rembrandt data set. (I) SH3KBP1 was highly expressed in NON G-CIMP than G-CIMP gliomas in Rembrandt data set. Lines show mean and S.E.M. Log-rank (Mantel-Cox) test was used to analysis the difference of Kaplan-Meier survival analysis. *, ** and *** indicate as p < 0.05, p < 0.005 and p < 0.001 respectively.