Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 11;10:583984. doi: 10.3389/fonc.2020.583984

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Song, Wang, Shi, Lu, Yuan and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

SH3KBP1 directly and physically interacts with and activates epidermal growth factor receptor (EGFR) signaling. (A) SH3KBP1 physically interacts with EGFR determined by Co-IP assay. (B) EGFR physically interacts with SH3KBP1 determined by Co-IP assay. (C) Confocal analysis of the co-localization of SH3KBP1 and EGFR in U87 cells. Cells were stained with SH3KBP1 (red), EGFR antibody (green) and merged images are shown. Scale bar: 50 µm. (D) Quantitative data for (C) (n=6). (E) Depletion of SH3KBP1 significantly inhibits EGFR signaling downstream genes expression. (F) Quantitative data for (E). *, ** and *** indicate as p < 0.05, p < 0.005 and p < 0.001 respectively.