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. 2021 Feb 11;10:583984. doi: 10.3389/fonc.2020.583984

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Copyright © 2021 Song, Wang, Shi, Lu, Yuan and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Depletion of SH3KBP1 inhibits mouse xenograft tumor growth in vivo. (A) Kaplan-Meier survival analysis of mice intracranially implanted with U87 cells with or without SH3KBP1 knockdown. n = 5, log-rank (Mantel-Cox) test. (B) Tumor weight was measured in mice after the mouse was sacrificed. (C) SH3KBP1 knockdown significantly inhibited mouse xenograft tumor growth. (D) Representative tumors derived from indicated cells were imaged. n = 5. (E) Immunohistochemistry staining analysis of Ki67, and p-STAT3 in U87 cells derived mouse xenograft tumors. Five tumors from each group were analyzed. (F, G) Quantitative data for (E). *, ** and *** indicate as p < 0.05, p < 0.005 and p < 0.001 respectively.