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. 2021 Feb 11;10:583984. doi: 10.3389/fonc.2020.583984

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Copyright © 2021 Song, Wang, Shi, Lu, Yuan and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Working model. SH3KBP1 physically interacts with and transduce epidermal growth factor receptor (EGFR) signaling to facilitate Glioma stem cells (GSC self-renewal and GBM cell proliferation.