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. 2021 Feb 11;11:620038. doi: 10.3389/fphar.2020.620038

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Copyright © 2021 Minutolo, Potestà, Roglia, Cirilli, Iacovelli, Cerva, Fokam, Desideri, Andreoni, Grelli, Colizzi, Muleo and Montesano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biological processes enrichment analysis of putative p-miRs regulated genes. (A) Enrichment analysis related to the genes associated to immune response and inflammation. (B) Enrichment analysis related to the modulated gene by the most conserved MO p-miRs. Up to the top 20 enriched clusters are shown colored by p-values. All the statistically enriched terms were identified (GO/KEGG terms, canonical pathways, hall mark gene sets, etc.), accumulative hypergeometric p-values and enrichment factors were calculated and used for filtering. Then 0.3 kappa score was applied as the threshold to divide the tree into term clusters. Created by Metascape [http://metascape.org].