Fig. 7.

Effect of CQ on bone resorption biomarkers in d-gal induced osteoporotic rats. Osteoporosis was induced in male rats via injecting d-gal of 200 mg/kg/day, i.p. for 8 consecutive weeks. Afterwards, osteoporotic rats were treated orally with CQ (10 mg/kg) for 4 successive weeks. 24 h after the last dose of CQ, serum RANKL (a), serum CTSK (b), and serum TRAP (c) were established via the sandwich ELISA technique. Results are expressed as mean ± S.E.M. (n = 10-12). Data were statistically estimated using one-way ANOVA followed by Tukey’s multiple comparisons test. Variances were deemed statistically significant when *p < 0.05 in contrast to the control group and ^@ p < 0.05 in contrast to D-gal treated group.