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. 2021 Feb 11;11:591975. doi: 10.3389/fimmu.2020.591975

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Copyright © 2021 Bugajev, Halova, Demkova, Cernohouzova, Vavrova, Mrkacek, Utekal, Draberova, Kuchar, Schuster and Draber

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The intracellular levels of S1P in ORMDL2 and/or ORMDL3 deficient BMMCs. (A, B) LC-ESI-MS/MS analysis of intracellular S1P levels in BMMCs isolated from WT mice, O2 KO mice, O3 KO mice, and O2,3 dKO mice, n = 3 in all groups. (A) The total levels of S1P (C18:1 and C18:0) are presented. (B) The levels of S1P derived from sphinganine C18:0 and sphingosines C18:1 are shown. Quantitative data are mean ± s.e.m., calculated from n, which show numbers of biological replicates. P values were determined by one-way ANOVA with Tukey’s post hoc test.