2.
已知代谢物的5种MR分析以及异质性检验和基因多效性检验结果
Results of 5 MR models of known metabolites and the heterogeneity and pleiotropy tests
| Metabolite | MR method | P | OR (95%CI) | Heterogeneity | Horizontal pleiotropy |
| MR Egger | 0.40033 | 2.74 (0.27-27.83) | 4.03E-6 | 0.7887 | |
| wme | 0.10592 | 1.94 (0.87-4.33) | |||
| Kynurenine | ivw | 0.00076 | 3.70 (1.73-7.92) | 0.00001 | |
| Simple mode | 0.33751 | 2.24 (0.44-11.34) | |||
| Weighted mode | 0.55621 | 1.47(0.41-5.31) | |||
| MR Egger | 0.57670 | 0.80 (0.39-1.68) | 0.67876 | 0.9706 | |
| WME | 0.06124 | 0.76 (0.57-1.01) | |||
| Mannitol | ivw | 0.04995 | 0.82 (0.66-1.00) | 0.76761 | |
| Simple mode | 0.16115 | 0.71 (0.46-1.10) | |||
| Weighted mode | 0.15848 | 0.74 (0.50-1.09) | |||
| MR Egger | 0.05559 | 0.79 (0.63-0.99) | 0.05882 | 0.5272 | |
| WME | 0.00979 | 0.82 (0.70-0.95) | |||
| N-aeetylornithine | ivw | 0.03116 | 0.83 (0.70-0.98) | 0.06825 | |
| Simple mode | 0.55030 | 0.84 (0.49-1.46) | |||
| Weighted mode | 0.01738 | 0.82 (0.71-0.95) | |||
| MR Egger | 0.23923 | 0.40 (0.09-1.79) | 0.16543 | 0.5468 | |
| WME | 0.05542 | 0.53 (0.28-1.01) | |||
| Glycine | ivw | 0.04711 | 0.62 (0.38-0.99) | 0.18519 | |
| Simple mode | 0.50131 | 0.68 (0.23-2.04) | |||
| Weighted mode | 0.33285 | 0.65 (0.27-1.54) | |||
| MR Egger | 0.18081 | 0.21 (0.03-1.38) | 0.53684 | 0.3566 | |
| WME | 0.01773 | 0.43 (0.22-0.86) | |||
| Myristoleate (14:ln5) | ivw | 0.03545 | 0.55 (0.32-0.96) | 0.51945 | |
| Simple mode | 0.28016 | 0.47(0.14-1.60) | |||
| Weighted mode | 0.10360 | 0.41 (0.17-0.99) | |||
| MR Egger | 0.63040 | 1.25 (0.52-3.03) | 0.79050 | 0.6550 | |
| WME | 0.11848 | 1.46 (0.91-2.36) | |||
| Heme | ivw | 0.02479 | 1.51 (1.05-2.16) | 0.83430 | |
| Simple mode | 0.33108 | 1.47(0.70-3.09) | |||
| Weighted mode | 0.32179 | 1.47 (0.71-3.05) | |||
| MR Egger | 0.11377 | 0.15 (0.02-1.17) | 0.54925 | 0.2373 | |
| WME | 0.07326 | 0.54(0.27-1.06) | |||
| 1 -Heptadecanoyl glycerophosphocholine |
ivw Simple mode |
0.02337 | 0.56 (0.34-0.92) | 0.47467 | |
| 0.07249 | 0.33 (0.12-0.94) | ||||
| Weighted mode | 0.12721 | 0.44 (0.17-1.13) | |||
| MR Egger | 0.00103 | 0.35 (0.22-0.57) | 0.78504 | 0.0088 | |
| WME | 0.00950 | 0.61 (0.41-0.88) | |||
| 1 -Methylxanthine | ivw | 0.00956 | 0.67(0.49-0.91) | 0.19300 | |
| Simple mode | 0.75693 | 0.87(0.36-2.10) | |||
| Weighted mode | 0.00090 | 0.45 (0.31-0.65) | |||
| MR Egger | 0.40292 | 0.88 (0.65-1.19) | 0.09187 | 0.9872 | |
| WME | 0.00075 | 0.77 (0.66-0.90) | |||
| Bradykinin, des-arg(9) | ivw | 0.02817 | 0.87 (0.77-0.99) | 0.11768 | |
| Simple mode | 0.56018 | 0.90 (0.64-1.27) | |||
| Weighted mode | 0.01041 | 0.78 (0.66-0.93) | |||
| MR Egger | 0.51601 | 1.50 (0.45-5.01) | 0.51997 | 0.7777 | |
| WME | 0.17896 | 1.60 (0.81-3.18) | |||
| gamma-Glutamylisoleucine | ivw | 0.00969 | 1.77 (1.15-2.73) | 0.57806 | |
| Simple mode | 0.02833 | 4.22(1.27-13.98) | |||
| Weighted mode | 0.35725 | 1.51 (0.64-3.54) | |||
| MR Egger | 0.06882 | 2.11 (0.96-4.62) | 0.36369 | 0.4005 | |
| WME | 0.03478 | 1.83 (1.04-3.20) | |||
| Succinylcarnitine | ivw | 0.01994 | 1.57 (1.07-2.29) | 0.37414 | |
| Simple mode | 0.09103 | 2.39 (0.89-6.43) | |||
| Weighted mode | 0.02542 | 1.94(1.11-3.40) |