3.

Leave-one-out法检验剔除混杂SNP后的3种代谢物MR分析结果

MR analysis results of the 3 metabolites after removing mixed SNP by leave-one-out method

Metabolite	MR method	nSNP	P	OR (95%CI)
	MR Egger	18	0.37779	0.72 (0.36-1.45)
	WME	18	0.31579	0.80 (0.52-1.23)
N-acetylornithine	ivw	18	0.46514	0.87(0.60-1.26)
	Simple mode	18	0.72676	0.88(0.44-1.77)
	Weighted mode	18	0.49999	0.85 (0.53-1.36)
	MR Egger	20	0.53604	1.12(0.78-1.62)
	WME	20	0.66920	1.04 (0.87-1.25)
Bradykinin, des-arg(9)	ivw	20	0.67259	1.03 (0.90-1.18)
	Simple mode	20	0.87332	0.97(0.69-1.38)
	Weighted mode	20	0.86910	0.97(0.69-1.36)
	MR Egger	45	0.15953	2.24 (0.74-6.74)
	WME	45	0.04549	1.95 (1.01-3.77)
Succinylcarnitine	ivw	45	0.06500	1.51 (0.97-2.32)
	Simple mode	45	0.13908	2.44 (0.76-7.79)
	Weighted mode	45	0.07326	2.08 (0.95-4.57)