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. 2021 Feb 11;11:588757. doi: 10.3389/fphar.2020.588757

FIGURE 3.

FIGURE 3

Effect of BAY60-6583 (0.1 mg/kg, i.p.) on the cytoarchitecture of the striatum and cortex 7 days after tMCAo. Upper part: Schematic brain picture of a coronal section (at Bregma = 0, König et al., 1964) showing the infarct area in a vehicle-treated rat. The two black circles indicate regions within the infarct area where photomicrographs were captured. (A–F) Representative microphotographs of H&E staining from dorsal striatum and fronto-parietal cortex of a sham (A,D), a vehicle- (B,E) and a BAY60-6583-treated rat (C,F). The white matter fascicula (f) are evidenced. Scale bar = 100 µm. Insets show magnifications of cells present in the square areas of panels (C–F). (G,H) Quantitative analyses of heterochromatic nuclei per striatal (G) and cortical areas (H) at coronal level AP = 0 from Bregma. Data represent the mean ± SEM (individual data points are shown) of three rats/group (*p < 0.02; **p < 0.005 BAY60-6583- vs. vehicle-treated rats, unpaired Student’s t test.