Figure 4. Schematic of the recycling and degradation of Ca_V channels.

Endocytosed Ca_V channels are either recycled or degraded. Rab11, a small GTPase that controls key events of vesicular transport, is suspected to be a major player in the recycling of Ca_V to the plasma membrane by interacting either with the Ca_Vα₁ subunit or with the α₂δ auxiliary subunit. Following their endocytosis Ca_V channels have been shown to be co-localized with Rab7, a marker for late endosomes and lyzosomes.