Table I.
Association between AMIGO2 expression and clinicopathological features.
| AMIGO2 expression | ||||
|---|---|---|---|---|
| Variables | 0 (n=82) (%) | 1 (n=126) (%) | 2 (n=59) (%) | P-value |
| Age, years | ||||
| <70 (n=127) | 35 (27.6) | 68 (53.5) | 24 (18.9) | 0.137 |
| ≥70 (n=140) | 47 (33.6) | 58 (41.4) | 35 (25.0) | |
| Sex | ||||
| Male (n=146) | 48 (32.9) | 64 (43.8) | 34 (23.3) | 0.480 |
| Female (n=121) | 34 (28.1) | 62 (51.2) | 25 (20.7) | |
| Tumor location | ||||
| Colon (n=190) | 62 (32.6) | 84 (44.2) | 44 (23.2) | 0.306 |
| Rectum (n=77) | 20 (26.0) | 42 (54.5) | 15 (19.5) | |
| Tumor size, cm | ||||
| <4.0 (n=103) | 34 (33.0) | 45 (43.7) | 24 (23.3) | 0.659 |
| ≥4.0 (n=164) | 48 (29.3) | 81 (49.4) | 35 (21.3) | |
| Histologya | ||||
| Differentiated (n=235) | 63 (26.8) | 115 (48.9) | 57 (42.3) | 0.001 |
| Undifferentiated (n=32) | 19 (59.4) | 11 (34.4) | 2 (6.2) | |
| Depth of invasionb | ||||
| T1/T2 (n=19) | 5 (26.3) | 9 (47.4) | 5 (26.3) | 0.863 |
| T3/T4 (n=248) | 77 (31.0) | 117 (47.2) | 54 (21.8) | |
| Lymph node metastasis | ||||
| Absent (n=139) | 46 (33.1) | 67 (48.2) | 26 (18.7) | 0.348 |
| Present (n=128) | 36 (28.1) | 59 (46.1) | 33 (25.8) | |
| Lymphatic invasionc | ||||
| ly0/1 (n=105) | 32 (30.5) | 52 (49.5) | 21 (20.0) | 0.761 |
| ly2/3 (n=162) | 50 (30.9) | 74 (45.7) | 38 (23.4) | |
| Vascular invasiond | ||||
| v0/1 (n=159) | 45 (28.3) | 81 (50.9) | 33 (20.8) | 0.327 |
| v2/3 (n=108) | 37 (34.2) | 45 (41.7) | 26 (24.1) | |
a
Histology: Differentiated, well or moderately differentiated adenocarcinoma; Undifferentiated, poorly differentiated adenocarcinoma, signet ring cell carcinoma or mucinous carcinoma.
b
T1, tumor invasion of the lamina propria or submucosa; T2, tumor invasion of the muscularis propria; T3, tumor invasion of the sub serosa or within adventitia; T4, tumor penetration of the serosa or tumor invasion of adjacent organs.
c
Lymphatic invasion: ly0-ly3, grade of lymphatic invasion.
d
Vascular invasion: v0-v3, grade of vascular invasion. χ2 test was used for the statistical analysis. AMIGO2, adhesion molecule with Ig like domain 2.