Table II.

Univariate and multivariate analyses of risk factors for liver metastases in patients with colorectal cancer.

	Univariate analysis			Multivariate analysis
Variables	P-value	HR	95% CI	P-value	HR	95% CI
Age (<70 vs. ≥70 years)	0.459	1.234	0.707–2.153
Sex (female vs. male)	0.025	1.941	1.085–3.473	0.012	2.260	1.200–4.254
Tumor location (colon vs. rectum)	0.992	1.003	0.543–1.854
Tumor size (<4.0 vs. ≥4.0 cm)	0.113	1.618	0.892–2.934
Histology (differentiated vs. undifferentiated)	0.210	0.528	0.195–1.433
Depth of invasion (pT1/2 vs. pT3/4)	0.155	2.957	0.665–13.151
Lymph node metastasis (absent vs. present)	0.004	2.340	1.318–4.155	0.014	2.165	1.170–4.006
Lymphatic invasion (ly0/1 vs. ly2/3)	0.252	1.407	0.785–2.522
Vascular invasion (v0/1 vs. v2/3)	0.008	2.150	1.223–3.778	0.010	2.220	1.206–4.088
AMIGO2 (0 vs. 1 vs. 2)	<0.001	2.511	1.651–3.817	<0.001	2.585	1.677–3.985

HR, hazard ratio; CI, confidence interval; AMIGO2, adhesion molecule with Ig like domain 2. Logistic regression analysis was used for the statistical analysis.