Table III.

Univariate and multivariate analyses of risk factors for metachronous liver metastases in patients with colorectal cancer.

	Univariate analysis			Multivariate analysis
Variables	P-value	HR	95% CI	P-value	HR	95% CI
Age (<70 vs. ≥70 years)	0.432	1.363	0.629–2.957
Sex (female vs. male)	0.449	1.344	0.625–2.888
Tumor location (colon vs. rectum)	0.984	1.009	0.438–2.321
Tumor size (<4.0 vs. ≥4.0 cm)	0.341	1.477	0.661–3.300
Histology (differentiated vs. undifferentiated)	0.564	0.690	0.196–2.429
Depth of invasion (pT1/2 vs. pT3/4)	0.311	2.772	0.356–21.603
Lymph node metastasis (absent vs. present)	0.027	2.431	1.107–5.341	0.040	2.357	1.042–5.332
Lymphatic invasion (ly0/1 vs. ly2/3)	0.105	2.022	0.863–4.741
Vascular invasion (v0/1 vs. v2/3)	0.318	1.475	0.687–3.167
AMIGO2 (0 vs. 1 vs. 2)	<0.001	3.175	1.785–5.733	<0.001	3.151	1.729–5.742

HR, hazard ratio; CI, confidence interval; AMIGO2, adhesion molecule with Ig like domain 2. Logistic regression analysis was used for the statistical analysis.