Table 1.
Baseline clinical characteristics by CKDc subgroups
| Non-CKDc Subgroup (N = 269) |
CKDc Subgroup (N = 196) |
P-value | |
|---|---|---|---|
| Estimated GFRd, (ml/min/1.73 m2) | 77 ± 14 | 49 ± 8 | |
| Age, (year) | 70 ± 8 | 73 ± 8 | < 0.001 |
| Age ≥ 75, (%) | 30 | 42 | 0.011 |
| Female sex, (%) | 33 | 50 | < 0.001 |
| Black race, (%) | 13 | 16 | 0.46 |
| Aspirin use, (%) | 52 | 55 | 0.56 |
| Statin use, (%) | 42 | 46 | 0.39 |
| Past or current smoker, (%) | 49 | 44 | 0.32 |
| SPRINT intensive SBP arm, (%) | 55 | 51 | 0.44 |
| Systolic blood pressure, (mmHg) | 139 ± 14 | 141 ± 14 | 0.075 |
| Diastolic blood pressure, (mmHg) | 78 ± 10 | 76 ± 11 | 0.082 |
| Pulse pressure, (mmHg) | 61 ± 13 | 65 ± 13 | 0.001 |
| CVD subgroupa, (%) | 9 | 13 | 0.23 |
| High Framingham risk subgroupb, (%) | 89 | 85 | 0.15 |
| Urine albumin creatinine ratio, (mg/g) | 8 (5, 14) | 11 (6, 41) | < 0.001 |
| Fasting LDL cholesterol (mg/dl) | 110 ± 30 | 110 ± 32 | 0.96 |
| Fasting HDL cholesterol (mg/dl) | 55 ± 15 | 54 ± 15 | 0.52 |
Results are presented as proportions (for binary variables) or as mean ± SD (for continuous variables other than ACR) or as median with interquartile range (for ACR)
aCVD subgroup was defined as one or more of MI, ACS, coronary revascularization, carotid revascularization, PAD with revascularization, > 50% stenosis of coronary/carotid/lower extremity artery; or AAA ≥5 mm
bFramingham risk score ≥ 15% for 10 years at SPRINT screening
ceGFR < 60 at SPRINT screening
dEstimated by 4-variable MDRD equation