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Effect of Mas receptor agonist, AVE0991, on the TRPC-mRNA content of (A) MNNG-HOS and (B) U-2 OS osteosarcoma cells. Cells were exposed to AVE0991 (1 µM) for 24 h. Subsequently, mRNA content was analyzed by reverse transcription-quantitative PCR. Data are presented as boxplots with medians, quartiles and an IQR ± 1.5 × IQR with outliers as indicated (Tukeys method; n=8; *P<0.05). IQR, interquartile range; TRPC, canonical transient receptor potential channels.
