Fig. 1.

Gestational sepsis causes low-weight offspring. a Clinical score evaluation of pregnant mice over time after induction of sepsis at E14 with Klebsiella pneumoniae instillation in the sepsis group and instillation of saline solution in the control group. Each point is the mean +/− SEM from at least 12 pregnant mice. b LPS solution (3 mg/kg, 10 mg/kg, and 15 mg/kg) and saline solution were administered in pregnant mice at E14. Mice were monitored over 48 h for clinical scores. c TNF-α, IL-1β, and IL-6 levels measured by ELISA in the placenta 24 h after induction of sepsis (i.e., E15). Each bar is the mean +/− SEM from 12 placentas. d Representative pictures and their body-size of offspring measured at P2 and P8. e, f Body-weight of offspring measured at P2 (e) and P8 (f). Each bar is the mean +/− SEM from 20 animals. *p < 0.05 compared saline to sepsis. **p < 0.05 compared 10 mg/kg, and 15 mg/kg to saline. ***p < 0.05 compared 5 mg/kg, 10 mg/kg, and 15 mg/kg to saline. NS not significant