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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Expert Rev Clin Immunol. 2020 Oct;16(10):1029–1042. doi: 10.1080/1744666X.2021.1828067

Figure 1: Autologous chimeric antigen receptor T-cell generation.

Figure 1:

For autologous CAR-T cell generation, peripheral blood mononuclear cells are collected from a patient by leukapheresis. T-cells are then transduced with a viral vector containing genetic information that encodes the receptor of interest. The CAR-Ts are expanded ex-vivo and then infused into the patient. Once infused, the CAR-Ts survey for the antigen of interest and are activated upon engagement with the target.