Duplicates removed	115
Excluded during initial screening (e.g. press releases; news reports; not relevant drug/indication; preclinical study; reviews; case reports; not randomized trial)	57
Excluded during writing (e.g. reviews; duplicate data; small patient number; nonrandomized/phase I/II trials)	75
Cited efficacy/tolerability articles	8
Cited articles not efficacy/tolerability	57
Search Strategy: EMBASE, MEDLINE and PubMed from 1946 to present. Clinical trial registries/databases and websites were also searched for relevant data. Key words were imipenem, cilastin, relebactam, Recarbrio, gram-negative bacterial infection. Records were limited to those in English language. Searches last updated 3 Feb 2021