Figure 4.

Amodiaquine only caused significant histological evidence of liver injury in the impaired immune tolerance model. Treatment with D-1-MT and AQ led to a slight increase in inflammatory foci. H&E-stained histology samples of the liver (10× magnification) in wild-type animals show normal liver architecture. In both groups treated with AQ in the PD-1^–/– animals, there is evidence of infiltrating lymphocytes surrounding the central vein/portal triad. The bulk of the inflammatory foci appear to be in the transitional and pericentral (zones 2 and 3) regions of the liver section.